Thank you for participating!

Thank you to all who contributed to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. Ultimately, over 1,000 ideas were submitted, with more than 42,000 votes. This remarkable response exceeded expectations and provided a wealth of ideas to draw upon as NHLBI moves forward. Please visit the NHLBI Strategic Visioning page to find out more about the NHLBI Strategic Visioning process.


Welcome to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. The Institute is gathering ideas for the most compelling scientific priorities in the four NHLBI Strategic Goals to address over the next decade.

Goal 3: Advance Translational Research

Submitted by (@wheeze)

Clinical Trial Methodology

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

Are the current methodologies for clinical trials still the best practices for conducting efficient clinical trials?

Voting

2 net votes
15 up votes
13 down votes
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Goal 3: Advance Translational Research

Submitted by (@fzaidi1)

Pulmonary Rehabilitation

What is the comparative effectiveness of short-term vs. chronic (indefinite) pulmonary rehabilitation on patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations)?

Voting

5 net votes
6 up votes
1 down votes
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Goal 1: Promote Human Health

Submitted by (@mtseng)

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their ...more »

Voting

1 net vote
5 up votes
4 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@teitelbaum)

Predictable and Steady Funding Growth

There is a need for a predictable, steady expansion of funding of NIH. The repetitive booms and busts in research funding are a primary source of the current instability of the biomedical research and training systems. Funding goals should not be simply “more”, or another “doubling”, but instead a trajectory of steady expansion of research funding that can be sustained over the medium-to-long term.

Voting

28 net votes
32 up votes
4 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Increased testing of new ideas

As indicated in two influential papers we have published, there are many potential contributing factors to obesity beyond those commonly discussed and studied and some of these are potentially modifiable. Increased research to understand whether these putative factors are really influential and whether they can be modified to produce benefits with respect to obesity are in order.

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0 net votes
1 up votes
1 down votes
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Goal 3: Advance Translational Research

Submitted by (@klaus0)

Integrate mechanistic and translational research

Other entries have asked for support for translational research. To be successful, this must be integrated with mechanistic research. Ideally. MD-PhD teams would get together. Challenges in translation: find formulation, preclinical toxicology, phase I trials to establish safety, biomarkers. Challenges in mechanism: RNA-Seq, Chip-Seq of relevant cells, KO mice by Cas-CRISPR, deep expertise in the relevant discipline.

Voting

28 net votes
37 up votes
9 down votes
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Goal 3: Advance Translational Research

Submitted by (@giralts)

Can we leverage exisiting registries to perform prospective trials and advance reduce the cost of doing research?

Current costs for multicenter randomized or non randomized trials are astronomical, and a major obstacle to rapid implementation of potential lifesaving discoveries. In the field of hematopoietic cell transplantation (HCT) their is a federal mandate to have a treatment outcome registry. Funds should be made available to leverage that registry to perform prospective trials either randomized or not since HCT programs need ...more »

Voting

123 net votes
154 up votes
31 down votes
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Goal 3: Advance Translational Research

Submitted by (@woneill)

Neglect of Valuable Heart Health Data

Routine bypass surgery generates left ventricle pressure and volumetric flow data which can be modeled by estimated parameters capable of determining a heart health index. This capability is also available online for the surgeon's

guidance and is applicable to any heart chamber.

Voting

-6 net votes
4 up votes
10 down votes
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Goal 1: Promote Human Health

Submitted by (@garobert)

Hierarchical control of cardiac excitability

Imbalances in membrane excitability underlie a broad range of cardiac arrhythmias and conduction defects. Although we now know the genes encoding almost all ion channels, we have little understanding of how the macromolecular composition and relative numbers of different channel types is achieved to exert exquisite control over membrane potential changes in time. Even minor changes in this balance can lead to sudden ...more »

Voting

1 net vote
2 up votes
1 down votes
Active