Goal 2: Reduce Human Disease

Biology of Red Blood Cell Alloimmunization

What determines which individuals will develop RBC alloimmune responses resulting in clinically meaningful sequelae?

 

This question encompasses: 1) the generation of alloantibodies that limit the availability of compatible blood or cause hemolytic disease of the fetus or newborn (HDFN); 2) the distinction between clinically significant and insignificant alloantibody responses, especially within alloantibody specificities known to have a potential for hemolysis; 3) the biology of hyperhemolysis in patients with sickle cell disease (SCD); and 4) therapeutic interventions to prevent and/or mitigate RBC alloimmunization and its sequelae, including those involving the donor, the recipient, or the RBCs themselves.

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Idea No. 457