Goal 2: Reduce Human Disease

Bringing Personalized Biochemistry and Biophysics to Bear on Problems of Personalized Heart, Lung and Blood Medicine

Precision medicine will provide unprecedented opportunities to tailor health care based on knowledge of personal patterns of genetic variations. These variations usually impact protein or RNA sequences, resulting in altered properties. These alterations can result in increased susceptibility to a particular disease or intolerance to common therapeutics. To take full advantage of knowing a patient’s set of gene variations, it will be critical to understand how the affected proteins are altered. Biochemistry, Biophysics, and Structural Biology have the tools to address this imperative in personalized medicine. An interface between these classical disciplines of basic medicine science and clinical medicine urgently needs to be developed.

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