a. Define the pathobiological changes that lead to severe exacerbations that cause hospitalizations
b. Define novel clinical and biological phenotypic characterizations of hospitalized patients who fail treatment that results in death or early readmission
c. Explore new or understudied therapies for treatment of acute COPD hospitalizations: antioxidant, non-steroidal anti-inflammatory (STATIN or antibiotic); aggressive treatment of airflow obstruction, treatment of hyperinflation, pulmonary rehabilitation, recognition and aggressive treatment of comorbidities, etc.