Goal 2: Reduce Human Disease

Can transcutaneous carboxyhemoglobin measure endogenous heme oxygenase activity?

Non-invasive measurement of transcutaneous carboxyhemoglobin (SpCO) by CO-oximetry has been shown to reflect disease activity in asthma, allergic rhinitis, Staphylococcal pneumonia/sepsis and to correlate positively with lung function in cystic fibrosis. Given published studies of heme oxygenase activity in these diseases as a reflection of oxidant or inflammatory activity, does measurement of SpCO reflect endogenous heme oxygenase activity, thus making it a simple, non-invasive way to follow this parameter?

Tags (Keywords associated with the idea)

Attachments

- [ Show all ]

Voting

-24 net votes
1 up votes
25 down votes
Active
Idea No. 373