Goal 2: Reduce Human Disease

Congential heart defects in diabetic pregnancies: a devastating reality

There is an urgent need to understand the mechanisms underlying diabetes-induced congenital heart defects (CHDs) through basic science research and biomarker identification in human maternal circulation. Majority of the current research in CHDs is related to genetic analyses; however, environmental factors contribute to the majority of human CHDs, but the underlying mechanism is unknown. There is 60 million worldwide reproductive age women having diabetes, and this number will be double in 2030. Even under the best clinical care, diabetic women are still three- to four-times more likely to have a child with CHDs than nondiabetic women. No effective prevention and intervention strategies are available for CHDs.

Tags (Keywords associated with the idea)

Voting

22 net votes
22 up votes
0 down votes
Active
Idea No. 894