Goal 3: Advance Translational Research

Detection of inflammatory monocytes as a biomarker of CVD

Coronary artery disease (CAD), of which atherosclerosis is a major contributor, costs the United States $108.9 billion each year. While a number of conventional risk factors such as smoking, diabetes and hypertension have been associated with CAD, their predictive performance is poor in the prevention of acute coronary syndrome (ACS). Despite the prevalence of ACS in our society, there are currently no molecular biomarkers that accurately identify patients with a high probability of coronary complications during and following cardiovascular interventional therapy. Thus, a predictive biomarker that facilitates early identification of those patients who are at the greatest risk of recurrent myocardial infarction or death is critical.

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Idea No. 556