Goal 2: Reduce Human Disease

Detection of rupture prone small aortic aneurysms

Critical challenges in the assessment of aortic aneurysms are: (1) Availability of reliable animal models that simulate the human pathology, (2) Availability of molecular imaging resources – identification of biomarkers, development of targeted imaging probes and pre-clinical imaging methods, and plasma markers that predict whether an aneurysm is prone to rupture or dissection, (3) Bringing together a wide array of multi-disciplinary experts (biologists, chemists, physicists, cardiologists, radiologists, and engineers) to focus on the common goal of aneurysm diagnosis to predict optimal timing of surgery or endovascular repair.

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Idea No. 22