Goal 2: Reduce Human Disease

Development of Optimally Hemostatic, Systemically Safe, Platelet Mimetics or Substitutes

What are the knowledge and technological gaps in production, evaluation and clinical translation of donor-independent platelets for transfusions? Specific questions include: a) How can stem or progenitor cells be expanded to maximize platelet production?; b) What are the hemostatically relevant design and function requirements and evaluation metrics for ideal/optimal “biologic” and “synthetic” platelets? c) What preclinical safety and quality assessments of donor-independent platelets will be required prior to clinical trials? And d) Are donor-independent platelets safe and effective for the prevention and treatment of thrombocytopenic patients?

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20 net votes
38 up votes
18 down votes
Idea No. 431