Goal 2: Reduce Human Disease

Devices for Immediate and Complete Peripheral Artery Occlusion

Approximately 50,000 peripheral artery embolization procedures are performed annually in the U.S. for a variety of clinical indications including stopping life-threatening bleeding; reducing blood flow to cancerous tumors; and diverting blood away from arterial aneurysms, arteriovenous fistulas, and other vascular malformations. Most of these procedures involve the endovascular implantation of wire coils or wire mesh vascular plugs to stimulate the formation of thrombus, resulting in blood vessel occlusion. These devices are difficult to place accurately, require substantial time and effort to achieve complete occlusion, and can be susceptible to vessel recanalization. Innovative devices that overcome these limitations are needed.

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Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Improved device technologies would have the potential to enable more precise device placement; faster, more complete, and more durable blood vessel occlusion; and fewer complications relative to currently available devices such as coils and vascular plugs.

Feasibility and challenges of addressing this CQ or CC :

This research would be best addressed through the NHLBI's SBIR program. Phase I would fund design and prototyping of devices, which would be tested in large animal models of vascular occlusion alongside currently available coils and vascular plugs. Phase II would fund development of the most promising devices in a range of sizes, design for manufacturing, design verification & validation, and preparation for first-in-human studies.

Name of idea submitter and other team members who worked on this idea : Howard Loree

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Idea No. 540