Goal 3: Advance Translational Research

Engineering Challenges for Next Generation VADs

Critical challenges to overcome include the development of non-platelet activating impellers and hypothrombogenic surfaces in modern ventricular assist devices (VADs). Percutaneous and transcutaneous electric drive systems will need to evolve, and clinical research is needed to reduce thromboembolism and bleeding (acquired von Willebrand syndrome). Adverse events may also be further reduced if smaller pumps, for partial hemodynamic support, can be placed with less invasive approaches (including devices deployable by percutaneous techniques). This can also be advantageous from a power consumption standpoint, and improvements are needed in high energy-density batteries and non-contact charging mechanisms.

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Idea No. 349