Goal 1: Promote Human Health

Examining the interface between physiological and pathophysiological angiogenesis and placental function in at risk pregnancies.

Abnormal placental function, characterized by retarded nutrient and oxygen exchange, and abnormal hormone and angiogenic growth factor production, is linked to a number of diseases that have a strong impact on maternal and fetal health. Perhaps of highest impact is pre-eclampsia, a disease affecting 5-8% of pregnant women worldwide. Moreover, issues related to a suboptimal intrauterine environment leading to growth retardation of the developing fetus are likely linked to adult disease, making this biomedical issue very far reaching. This problem is particularly timely, given the recent initiation of the Human Placenta Project at the NICHD, and adding this compelling question to the NHLBI Strategic Vision will create important synergies.

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Idea No. 889