Goal 1: Promote Human Health

Extreme makeover: harnessing adaptation mechanisms for therapy

What extreme adaptive physiological mechanisms in heart, lung, and blood systems might have the greatest potential to be targeted or employed in therapeutic strategies? Human physiology, including the heart, lung and blood systems, is known to possess extreme adaptive mechanisms to counter extreme conditions or unusual situations. Although some studies are being done, many of these mechanisms have not been fully explored or harnessed for therapeutic strategies. As an example, HLB systems are known to have built-in mechanisms to cope with high altitude and extreme temperature situations but these mechanisms may not have been fully uncovered or explored for therapeutic potential.

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Idea No. 246