Goal 2: Reduce Human Disease

Fibrosis Across Organs: Bringing Together Investigators of Fibrosis of the Heart, Lungs and Bone Marrow

Fibrosis can affect essentially any tissue or organ, including the heart, lungs and bone marrow. Effective anti-fibrotic therapy has long been elusive, and transplantation has been the only therapy capable of restoring patient function as fibrotic diseases progress to organ failure. Although these diseases present clinically with organ-specific manifestations, they are now thought to share many common pathogenetic mechanisms. The critical challenge is to capitalize on emerging synergies between researchers focused on fibrotic diseases across NHLBI divisions, to foster research into shared pathways, and to foster clinical trials of agents targeting these pathways, for cardiac, pulmonary and myelofibrosis.

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Idea No. 768