Goal 2: Reduce Human Disease

Funding Limitations Block Intervention Research

The cap on R01 research grants at $500,000 per year has not changed in over 20 years. In the current fiscal crisis for research it has become an immovable block to submitting intervention studies (randomized clinical trials on treatment). Routine advice from NIH staff is to not even try for a larger study. The cap applies to every year, so one can design a trial that costs less than $2.5 million but exceeds $500,000 in one year (during recruitment, in general) and still be stymied. This block is requiring investigators to limit their vision to data-only, observational, or natural experiments. These can never substitute entirely for trials.

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Idea No. 834