Goal 2: Reduce Human Disease

How should platelet (PLT) transfusions be used to treat active bleeding?

Multiple randomized controlled trials have been performed to evaluate the use of prophylactic PLT transfusions in non-bleeding, thrombocytopenic hematology-oncology patients. However no high-quality data exist to guide PLT transfusions in actively bleeding patients inclduing pediatric and adult medical and surgical patients. After hematology-oncology patients, cardiac surgery patients are the next largest group of PLT transfusion recipients. Cardiac surgery patients use 10-25% of all blood products in the U.S. Bleeding shortly after cardiac surgery is a common and clinically important problem and excessive bleeding is an independent predictor of decreased survival. Optimal PLT transfusion therapy in this setting needs to be defiined.

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Idea No. 435