Goal 3: Advance Translational Research

Human Heart Systems Biology

In the human failing heart, it is the systems biology that ultimately fails: electrical, mechanical, and chemical perturbations in their function do not manifest in isolation, but critically impact on each other in health and disease. Investigation of human myocardium, unlike inbred rodent models, is challenging since no two humans are identical. There is a need for the collection and assessment of clinical patient data, biometrics, and in vivo tests, such as ECG, Echo, and MRI as well as in vitro data, such as mechanical and electrical parameters of the human myocardial muscles and cells. These data, combined with genomics, proteomics, and histology of the very same human heart, repeated in a large number of hearts, would be needed.

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Idea No. 738