Goal 1: Promote Human Health

Human normal variation and resilience across lifespan

What is the measureable normal human variation at the -omic, cellular, organ, and system levels within the population and across the lifespan?

• What are the range of normal human cellular functions that create resilience at all levels—cells, organs, organ systems?

• What inter-organ, tissue, and cellular communications maintain individual health and the health of populations?

• How do we understand why individuals with the same genetic risk and/or environmental exposures have differing susceptibility to disease? (COPD and smoking, sickle cell disease, IPF) What factors render individuals or populations susceptible or resilient?

• What are the processes and genes that prevent or ameliorate disease in susceptible patients?

Tags (Keywords associated with the idea)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

• Will provide a better definition of what is normal in order to better interpret and exploit the big data available through increased personalized monitoring and use of EMRs.

• Insights into the underlying mechanisms of resilient phenotypes will provide new paradigms for disease prevention and treatment.

Feasibility and challenges of addressing this CQ or CC :

Feasibility will depend on the level of investment (large) and accessibility to commons data.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Idea No. 5