Goal 2: Reduce Human Disease

Impact of Successive Acute Lung Injury on Subsequent Challenge

A great deal of focus has been placed on understanding chronic lung diseases such as asthma and CF. Long term changes in inflammatory and epithelial processes are well documented in this area. However, less research has addressed the impact of successive pulmonary injuries and how these seemingly acute events shape the lung response. This is the crux of the multi-hit theory regarding interstitial lung disease. Many acute infections result in epigenetic and cellular reprogramming of the lung which persists much longer than the disease state (for example, influenza). Most researchers welcome the concept that early life events impact lung function years later. However, there are few models of serial infection addressing this hypothesis.

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Idea No. 592