Survival has improved but neurobehavioral disabilty remains a common complication with adverse impacts on quality of life, educational and occupational attainments, and resource utilization. There is increasing evidence that brain development is abnormal, and leads to a rrisk of peri-operative brain injury.
Studies are needed to;
1. Further define the prevalence and spectrum of neurobehavioral disability.
2, Understand the mechanisms underlying abnormal brain development and peri-operative brain injury.
3. Develop new neuroprotective strategies, possibly to be implemented during fetal life.
4. Understand the role genomic variation plays in the risk of brain injury and neurodevelopmental disability.