Goal 3: Advance Translational Research

Including subjects with both COPD and asthma in clinical trials

Subjects with both COPD and asthma are typically excluded from clinical trials, but they represent an important segment of the chronic airflow obstruction population. Defining this combination diagnosis is difficult, but requiring a significant smoking history (e.g. 10 pack years), chronic airflow obstruction (GOLD stage 2 or greater after bronchodilator), age > 45, and childhood onset of asthma could identify the relevant population. A clinical trial of any of the commonly used COPD drugs—tiotropium, LABA/ICS, azithromycin, or roflumilast—with exacerbation frequency as the outcome would be very valuable.

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Idea No. 1595