Goal 3: Advance Translational Research

Increasing Regenerative Medical Strategies in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a complex, progressive condition characterized by high blood pressure in the lungs and restriction of flow through the pulmonary arterial system. Current PAH therapies mainly act of the vasoconstrictive component of the disease; however there is a widely accepted view that another contributor to the disease is an abnormal overgrowth of cells that line the pulmonary arteries, which ultimately decreases the space in the vessels through which blood can flow. There are currently no approved therapies to act against this abnormal “pulmonary vascular remodeling” and prevent or reverse the overgrowth of these hyperproliferative cells.

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Idea No. 778