Goal 1: Promote Human Health

Intersecting Developmental Biology with Vascular Physiology and Biology

Although many think of the vasculature as a lump sum of vessels that all react in a similar fashion to a certain stimulus, e.g., alpha-adrenergic activation, this is not the situation. For example, coronary resistance vessels show little to no direct response to alpha-adrenergic activation while resistance vessels in most organs show marked constriction. Another example is the response of different vessels to angioplasty procedures--vascular medicine interventionists describe very different restenosis rates in renal, carotid, and coronary vessels after angioplasty. Part of this challenge is to understand the basis for this heterogeneity by advocating investigations combining developmental biology with vascular biology and physiology.

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Idea No. 641