Goal 3: Advance Translational Research

Lipid and lipoprotein metabolism in the CNS

The analysis of lipoprotein metabolism has traditionally been restricted to the easily accessible circulation and peripheral tissues. Very little work has been done behind the blood brain barrier, where many of the lipid carrying or metabolizing genes are also expressed. Yet we know very little about their functions there, although for instance ApoE4 is THE primary risk factor for late-onset Alzheimer's disease. Conventional neuroscientists are ill-equipped to address this problem. Thus, lipoprotein reseearchers need to be encouraged to apply their expertise to the -admittedly- much harder problem of defining the lipid/lipoprotein driven mechanisms that protect the brain from degeneration.

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Idea No. 608