Goal 2: Reduce Human Disease

Mechanisms of Uterine Hemostasis

What are the mechanisms of uterine hemostasis?

Endogenous mechanisms of uterine hemostasis protect women from the bleeding challenges of miscarriage, childbirth, and menstruation. Dysregulation of these mechanisms has implications for the critical public health problems of hormonally-induced venous thromboembolism and hormonally-induced arterial thromboembolism (myocardial infarction and stroke). Our current understanding from multiple epidemiological studies, including the Women’s Health Initiative, is that female sex hormones increase the risk of thrombosis, but what is not understood is by what mechanisms female sex hormones induce thrombosis or to what extent these mechanisms either directly or indirectly induce thrombosis.

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Idea No. 872