Goal 2: Reduce Human Disease

New ideas from drug-induced cardiotoxicity

What are the fundamental mechanisms of drug, chemical, or biologics-induced cardiotoxicity (e.g., which proteins or signaling targets are most vulnerable)? Would such knowledge lead to understanding of the most critical signaling systems and contribute to development of new therapeutic (cardioprotective) strategies?

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Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Beyond helping with real-world problems (e.g., cancer drug cardiotoxicity), understanding of toxicity mechanisms in the CV system enables a different level of understanding. For example, acute toxicity testing is probably akin to crash testing of the CV system, permitting us to see where things break. Thus there is potential to lead to a fuller understanding and novel therapeutic ideas.

Feasibility and challenges of addressing this CQ or CC :

As the number of newer and more powerful therapeutics grow, their risk of adverse impact on the CV system grows. This is in part due to insufficient knowledge of toxicity mechanisms and lack of effective drug-screening tools during drug development. This field primarily lacks researchers.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Idea No. 310