Goal 3: Advance Translational Research

New treatment for HIV and HIV-related lymphoma

Highly active antiretroviral therapy (HAART), while clearly invaluable, does not halt growth or proliferation of HL, in fact, while AIDS-defining malignancies like Kaposi’s sarcoma (KS) and non-Hodgkin’s lymphoma (NHL) have declined thanks to HAART, the incidence of HL in HIV patients has actually increased, from 14 times higher than that of non-HIV patients in the pre-HAART era to 32 times higher in the HAART era. Typical HL therapies – chemotherapy, radiation and monoclonal antibodies – are not applicable as they hasten progression of HIV by exacerbating underlying immunosuppression. This gap in our clinical armamentarium calls for the development of innovative therapies

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Idea No. 358