Goal 3: Advance Translational Research

Next Stage of COPD Discovery

1) Refinement of COPD subphenotypes for therapeutics, diagnostics and mechanistic interrogation. The NIH should encourage a strong focus on a) rigorous, mechanistically-reinforced definitions (chronic bronchitis, emphysema (with and without obstruction), frequent exacerbators, combined pulmonary fibrosis and emphysema) and 2) the development and optimization of animal model systems that replicate the different subphenotypes.

2) Development of new research translational grants that traverse clinical to basic proposals. Basic researchers are financially disadvantaged if they need a recruitment arm and clinical researchers face oppressive reviews if they have basic projects.

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Idea No. 694