Goal 1: Promote Human Health

Nicotine abuse and fetal programming of heart ischemic disease

It is well-known that cigarette smoking is a major risk factor of heart ischemic disease. However, little information is known about the maternal smoking and fetal programming of heart ischemic disease in adulthood. Recently, e-cigarette (nicotine use) during pregnancy is a worldwide health concern. Epidemiologic studies have indicated that cigarette smoking during pregnancy is associated with an increased risk of cardiovascular diseases in postnatal life. However, no direct work has been done on the health effects of e-cigarettes products on fetal programming of adult heart ischemic disease. Furthermore, the epigenetic mechanisms underlying those fetal stress-induced development of heart ischemia-sensitive phenotype are largely unknown.

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Idea No. 780