Goal 3: Advance Translational Research

Overcoming barriers to translational regenerative medicine

Current stem cell based approaches to translational medicine predominantly show modest efficacy. Most research rest on accepting existing limitations and focusing upon "tweaks" to the experimental model rather than taking on important barriers head on. The efficacy of stem cell-based regenerative medicine will never be fully realized unless we stop trying overly simplistic approaches such as"more is better" and start addressing real issues such as cell survival, engraftment, commitment, aging, genetic variability, persistence, cell-cell communication. proliferation, and the tissue environment. Overcoming these critical barriers to optimize regenerative cell therapy needs to be a major focus of the future for translation implementation.

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Idea No. 506