Goal 2: Reduce Human Disease

Persistent Burden of HIV Infection on Lung Health in the U.S. and Globally

Despite the advent of HAART the lung and vascular compartment continue to bear the brunt of complications associated with HIV infection. Potential causes include the establishment of HIV latency in the lung, inability of current therapeutic agents to treat latent reservoirs, inadequate immune reconstitution in the lung, and persistent impairment of normal lung homeostasis after treatment (i.e. persistent alterations in the lung microbiome, persistent cofactors such as smoking habits, persistent lung inflammation). Comprehensive and collaborative approaches are needed to address why the lung remains uniquely susceptible to complications in the HAART era.

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Idea No. 517