Goal 2: Reduce Human Disease

RFA on EC-cardiomyocyte interactions in the mechanisms and treatments of cardiovascular diseases

Often under recognized, the cardiac endothelial cells are highly abundant in the heart, and may have important roles in modulating cardiac function, besides simply serving as structural component of blood vessels. Evidences of ours and others have indicated an emerging role of cardiac endothelial cells signaling to cardiomyocytes to mediate important pathophysiological responses. Nonetheless, detailed mechanisms of interaction between these cell types in the development and treatment of cardiovascular diseases such as ischemia reperfusion injury and arrhythmogenesis remain to be fully elucidated. Therefore I propose to establish a focus group on this topic, ideally a RFA program to intensively explore this area.

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Idea No. 839