Goal 2: Reduce Human Disease

Redox regulation of cardiovascular and lung disease through thiols

Redox imbalance as represented by alterations in oxidative versus reductive stresses are well appreciated to occur during nearly all forms of cardiovascular and lung diseases. However, specific molecular mechanisms responsible for these changes remain largely unknown and poorly organized. Study of redox biology principals has revealed that protein cysteine thiols are a unique target for redox posttranslational modifications thus establishing a ‘thiol switch’ for protein function. Unfortunately, little specific information on various levels is known regarding the importance of ‘thiol switches’ for cardiovascular and pulmonary health or disease representing a critical challenge.

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Idea No. 613