Goal 2: Reduce Human Disease

Reduce the immunological burden of Heart Transplantation.

The research in the field of heart transplantation is importantly targeted to minimization of the undue toxicity of immunosuppressive regimens. This practice is limited by the natural tendency to develop chronic and humoral rejection if immunosuppression is too low.

Allocation of organs in Heart Transplantation (HTx) is traditionally limited by the logistic of donation (Cold Ischemic Time) and by the urgency of recipients. In the era of Machine Perfusion (extending cold ischemic time) and of mechanical circulatory support (extending waiting list time and reducing the urgency of HTx) could we think to allocate - in selected settings - the organs trying to reduce the immunologic burden and permitting a safer drug minimization?

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Idea No. 1058