Goal 2: Reduce Human Disease

Reducing the toxicity and morbidity of blood transfusions

Transfusion is the most commonly prescribed inpatient procedure. Blood transfusions have been shown in randomized trials to predispose to novel side effects. These include nosocomial infection, multi-organ failure, thrombosis and mortality due to these causes. Even in an era of more restrictive transfusion, there is an urgent need to understand and mitigate the mechanism(s) of these effects. Some patients will always need transfusions. It is unlikely that any other therapy will replace transfusions for trauma patients or patients with aplastic anemia. It is known that simple technologies such as leukocyte reduction may ameliorate some of these effects. Similar techniques, such as washing, rejuvenation and others require evaluation.

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Idea No. 106