NHLBI directed research should be abandoned and switched to investigator initiated research. I respectfully suggest read the following assay by Brown and Goldstein, Science 2012; 338: 1033-1034
The best way to run the science sponsored by the NIH (or NHLBI) is not to guide it (analogy to running science from ivory tower) but let the investigators decide what is worth pursuing. Get rid of NHLBI-directed research initiative and programs and leave it to the collective mind of thousands of investigators to come up with research ideas Likewise, minimize the influence of administrators with a science degree in building their research portfolios as wall street fund managers do. Back to basic fundamental discoveries is the way to go.