There should be a study for prevention of Airflow Obstruction Progression. Rationale: All diseases have a prodrome followed by an early face of disease progression. Complex medical chronic diseases can only be slowed through the addition of several interventions all of which contribute to a final improvement of prognosis (witness CV diseases).
Definition of “Early Disease”: Would be aimed at patients with airflow obstruction patients <50 years who have mild disease and faster rate of FEV1 decline
Interventions: Risk exposure control, Vaccination & promotion of healthy lifestyle (exercise, weight control), Pharmacotherapy
Outcomes looked at: Rate of FEV1 decline & several secondary outcomes related to: QoL, biomarkers & health utilization