Goal 3: Advance Translational Research

Study on the Immunologic Effects of ECP (Extracorporeal Photopheresis)

The clinical use of extracorporeal photopheresis (ECP) is expanding. It is known that dendritic cells plays critical role key to its efficacy, but exactly how ECP impacts other immune components and their interactions is not fully understood. There are many unanswered questions such as: “ What are the critical factors in ECP that result in a shift of the dendritic cell population from immune activating to immune tolerant? Is phagocytosis of the apoptotic CD3+ T-cell population a critical element? Under what conditions does ECP promote tumor immunization and can this be expanded beyond CTCL?” please see N. Ratcliffe et al. / Transfusion Medicine Reviews 29 (2015) 62–70.

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Idea No. 730