Goal 3: Advance Translational Research

Study on the Immunologic Effects of ECP (Extracorporeal Photopheresis)

The clinical use of extracorporeal photopheresis (ECP) is expanding. It is known that dendritic cells plays critical role key to its efficacy, but exactly how ECP impacts other immune components and their interactions is not fully understood. There are many unanswered questions such as: “ What are the critical factors in ECP that result in a shift of the dendritic cell population from immune activating to immune tolerant? Is phagocytosis of the apoptotic CD3+ T-cell population a critical element? Under what conditions does ECP promote tumor immunization and can this be expanded beyond CTCL?” please see N. Ratcliffe et al. / Transfusion Medicine Reviews 29 (2015) 62–70.

Tags (Keywords associated with the idea)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Further basic science research is necessary to elucidate how these cellular activities are functionally integrated and regulated.

It is critical to understand the role of ECP in immunomodulation and tumor immunotherapy, thus better clinical protocol can be developed with optimal immune balance to achieve therapeutic target and minimize side effects.

Feasibility and challenges of addressing this CQ or CC :

Studying immunomodulation in ECP patients offers a true bench to bedside opportunity. Experimental protocols can utilize in vitro, animal and clinical study designs targeted at immunotolerance and tumor vaccines

There are a very limited number of animal models available for apheresis research in general, and studies of the mechanism(s) of action of photopheresis have been very limited as well as difficult and expensive to perform. Funding support is critically needed in this area.

Name of idea submitter and other team members who worked on this idea : Yanyun Wu on behalf of ASFA


91 net votes
108 up votes
17 down votes
Idea No. 730