Goal 2: Reduce Human Disease

Targeting Preclinical Diastolic Dysfunction to Prevent Heart Failure

Heart failure (HF) affects over 5 million American adults, and projected estimates show growth of this epidemic by 25% over the next 15 years as the population of the United States continues to age. Heart failure with preserved EF (HFpEF) encompasses 50% of all heart failure cases. Preclinical diastolic dysfunction (PDD) is defined as normal systolic function, moderate or severe diastolic dysfunction determined by Doppler criteria but with no symptoms of HF (ACC/AHA Stage B HF). In the general adult population the prevalence of PDD is approximately 28%. In PDD, the incidence of HF development 12% over 3 years, hence targeting PDD prior to development of symptoms can reduce development of heart failure.

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Idea No. 1059