1. Monotherapy with a quinolone vs combination therapy with a 3rd generation cephalosporin. The issue of the best antibiotic treatment for severe CAP has been a major area of contention now for a decade and it is the most common cause of infectious death in the United States.
2. Combination therapy vs monotherapy for pneumonia due to Pseudomonas. This is another major area of contention – for nearly 2 decades, and generates enormous economic cost and high mortality and morbidity in ICUs.
3. 3 days vs 5 days vs 7 days of antibiotic therapy in community-acquired pneumonia.
Nearly 80 years of antibiotics and we still don't know how long to treat patients for with pneumonia.