Goal 3: Advance Translational Research

Translational research need not be mechanistic

Translation means laying the groundwork to advance an idea into the clinic. Late-stage translation means doing what FDA and IRBs require to obtain approval for an IND or an IDE and the associated protocol to test a new idea in humans. Mechanism is the mantra for investigator-initiated research in NIH study sections, but translation is often painstaking detailed work that follows mechanistic investigations, which typically come at the proof-of-concept level. The critical challenge here is, HOW DO WE ENSURE THAT STUDY SECTIONS VALUE REAL TRANSLATION WITHOUT MECHANISTIC INSIGHTS? This is what is often required to traverse the oft-cited Valley of Death.

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-14 net votes
9 up votes
23 down votes
Idea No. 504