Goal 2: Reduce Human Disease

Treatment Options for Diabetics and Impact on Cardiovascular Health

As a clinician, over the years I have noted major differences in adverse cardiovascular outcomes in diabetics who are treated with insulin +/- oral agents compared to those only treated with oral agents. Cardiovascular events occur much less often and at a much later timeframe in diabetics ("Type 2/adult onset") treated with insulin as the primary method. Even with newer agents, there may be slight improvement, but those treated with insulin always do better. Diabetics on oral agents develop c-v problems generally within five years of diagnosis. This study would involve long-term research, but in the end it could avoid or delay nephropathy/dialysis, microvascular disease/leg ulcers and blindness.

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Idea No. 783