Goal 2: Reduce Human Disease

Understand the Impact of Thrombosis in Children with Cancer

CC: Despite the potential impact that venous thrombotic events (VTE) have on children with cancer, several unresolved issues remain. To date, we are yet to understand:

- incidence/prevalence of VTE according to cancer type/staging

- ideal imaging modalities to diagnose/follow VTE

- thromboprophylaxis according to thrombosis risk stratification (development of VTE predictors)

- efficacy/safety to anticoagulate children with cancer, whose prothrombotic and pro-bleeding risk factors are constantly changing

- understand acute/longterm complications related to VTE

- role of anticoagulation on overall- and disease-free survival

- molecular tumor markers and cross talk between tumor aggression and coagulation/inflammation cascades

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Idea No. 725