Goal 1: Promote Human Health

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to sleep loss varies from one variable to another - e.g., sleep physiological responses to sleep loss are distinct from stress responses; and a person's vulnerability to cognitive impairment is task-dependent and thus not predictable by biomarkers. A fundamentally new understanding of trait vulnerability to sleep loss is needed.

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