Goal 1: Promote Human Health

Updating level C evidence in Clinical Guidelines

Clinical Guidelines depends on good science. Despite this, only 11% of guidelines that reported level of evidence in 2009, had level of evidence A while 48% had level C. Studies have shown that recommendations based on Level of Evidence C (or their equivalence) are significantly less reliable and may be downgraded, reversed or omitted when better evidence is available.

I propose a comprehensive review of ACC/AHA guideline recommendations for Class 1 and possibly Class 2 recommendations that have Level of evidence of C, followed by a quantification of the potential impact from a guideline recommendation reversal. The resultant list could subsequently be used to guide researchers’ and funding agency priorities for new studies.

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Idea No. 1078