Goal 3: Advance Translational Research

Using "omics" technologies to define responders to drug therapies

Metabolomic and proteomic technologies open tremendous avenues to define at the systemic level and, in the case of the lung, the organ level response to drug and non-drug interventions. The concept of responders and non-responders to therapies is poorly defined and hampers development of biomarkers and appropriate animal models. Omics technologies can bridge these important areas. In lung disease, breath analysis could be a major component.

Tags (Keywords associated with the idea)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC :

This work would be slow because it requires analyzing profiles of metabolomes from many drug classes. This long term project is needed to better understand the biological effects of new drugs coming to market.

Name of idea submitter and other team members who worked on this idea : nkenyon

Voting

7 net votes
13 up votes
6 down votes
Active
Idea No. 732