Goal 2: Reduce Human Disease

What is the Role of Macrophages in Pathogenesis of HHT

Alk 1 or Endoglin deficient endothelial cells promote recruitment of monocytes/macrophages and differentiation of them can play a critical role in development of arteriovenous malformations. Will targeting macrophage recruitment or activation instead of angiogenesis result in greater understanding leading to new therapeutic targets to control disease?

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Idea No. 1075