Goal 2: Reduce Human Disease

What is the role of chronic inflammation in lung complications in the HAART era?

With the advent of HAART HIV-infected subjects are living longer. Lung infectious complications so common in the early stages of the HIV epidemic have been replaced by those associated with chronic inflammation (COPD, pulmonary hypertension, lung cancer). Furthermore, this chronic inflammation is likely contributing to premature vascular complications (i.e coronary disease) seen in this population. All of these complications could be characterized as a premature aging phenotype. Understanding the cause of persistent inflammation in HIV-infected subjects is critical for preventing these complications. These studies would also have significant implications for a better understanding of the aging process in a non HIV-infected population.

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Idea No. 516