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NHLBI should continue to support prospective cohort studies, projects, and investigators that evaluate longitudinal outcomes in minority populations where longitudinal data are scarce and difficult to obtain. The resources generated remain invaluable and can be used to conduct crosscutting translational research (i.e. the Jackson Heart Study, Strong Heart Study, and others).

Condom designed to protect a males pubic areas and scrotum, fingers and hands from coming in contact with infectious fluids. The adoption of a shield to reduce the occurrence of HPV and other STI infections. This is the first and only condom in the world that uses a latex shield which is designed to protect a promiscuous males fingers and hands from HPV and other infectious human secretions that may be in fluids,. We ...more »

How can we provide better support for junior investigators who are transitioning from K Award to R Award funding?

Multiple lines of evidence suggest that the beneficial effects of cell therapy are mostly indirect, but what are the key factors responsible for these indirect benefits?

Can we improve the thresholds for defining hypertension in children and adolescents based on risks for future adverse cardiovascular sequelae? In addition, can we to better understand how early identification of hypertension impacts long term health outcomes?

Combining Research Efforts to Find Answers Faster - collaboration across organs should be encouraged and practiced.

Vaccination responses are poor early after hematopoietic cell transplantation and in the context of cytotoxic chemotherapy. To design effective vaccination strategies it is critical to understand the immune correlates of protection. There is a need to study strategies to study and improve vaccine efficacy in this growing population of immunosuppressed individuals that is increasingly of advanced age.

Currently, there are limited, if none, funding resources to synthesize and screen potentially therapeutic molecules, based on supportive findings in cells, biopsy tissues from the patients with the disease in question, and the preliminary data to support the development of a series of compounds to screen them for their pharmacokinetics, pharmacodynamics, toxicity and use in clinically-relevant large animal models.

Are existing neurohormonal antagonist drugs effective in HFPEF ?

Women differ from men in their manifestations of ischemic heart disease (IHD). They also differ from men with respect to prevalence of psychosocial factors and vulnerability to specific mental disorders. Young women, in particular, appear to be highly susceptible to the adverse cardiovascular effects of psychosocial stress. Those who already have clinical manifestations of IHD display high psychosocial burden which could ...more »

What is the connection between the gut microbiome and the development of hypertension?

Do patients with congenital heart disease have the same, higher, or lower risk for coronary artery disease as they age into adulthood?