Thank you for participating!

Thank you to all who contributed to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. Ultimately, over 1,000 ideas were submitted, with more than 42,000 votes. This remarkable response exceeded expectations and provided a wealth of ideas to draw upon as NHLBI moves forward. Please visit the NHLBI Strategic Visioning page to find out more about the NHLBI Strategic Visioning process.


Welcome to the National Heart, Lung, and Blood Institute (NHLBI) Strategic Visioning Forum. The Institute is gathering ideas for the most compelling scientific priorities in the four NHLBI Strategic Goals to address over the next decade.

(@urdesai)

Goal 4: Develop Workforce and Resources

How will we train younger generation of scientists with skils in understanding the glycans?

Recent results suggests that glycans play critical roles in human physiology and pathology. Understanding glycan protein interactions may lead to next generation of drugs. But limited research is being funded on understanding structure - function relationships on glycans. Likewise, we are training very few researchers in the glycosciences. More programs are needed to impart glycoscience knowledge at the undergraduate,... more »

Voting

-21 net votes
6 up votes
27 down votes
Active
(@gaynor)

Goal 1: Promote Human Health

Improving longterm outcomes after surgery for congenital heart disease

Survival has improved but neurobehavioral disabilty remains a common complication with adverse impacts on quality of life, educational and occupational attainments, and resource utilization. There is increasing evidence that brain development is abnormal, and leads to a rrisk of peri-operative brain injury. Studies are needed to; 1. Further define the prevalence and spectrum of neurobehavioral disability. 2, Understand... more »

Voting

18 net votes
23 up votes
5 down votes
Active
(@nhlbiforumadministrator)

Goal 4: Develop Workforce and Resources

Better oversight and transparency for diversity in our research portfolio

There needs to be better oversight and transparency for diversity in our research portfolio to include a steady pipeline of young investigators and to facilitate the entry of pediatricians into the research work force. Specifically, workforce diversity should be considered in addition to scientific merit in determining funding priorities.

Voting

1 net vote
1 up votes
0 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Asthma self-management

Study patient-provider communication of asthma self-management requirements to see where gaps in communication may contribute to suboptimal self-management decisions. Examine patients’ decision-making in the home management of asymptomatic and acute. Compare different approaches to the delivery of asthma self-management education and best practices for supporting the patient as they gain competency in this area.

Voting

1 net vote
1 up votes
0 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Paracrine Signaling in the Heart

We need to improve the understanding of the molecular and physiological bases of paracrine signaling of heart, and use the knowledge gained to develop improved, effective approaches to diagnose, treat, and prevent cardiac disorders.

Voting

13 net votes
27 up votes
14 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Inhaled antibiotics for patients with bronchiectasis

Many pharma companies are developing inhaled antibiotics for patients with bronchiectasis, recognizing the increasing market (over 110,000 patients in the US). These drugs cost thousands of dollars per year and will be heavily marketed and heavily used, as there are limited options for these patients. It is unknown if rotating oral antibiotics (cost is a fraction of the inhaled ABx) would yield similar results.  A Cochrane... more »

Voting

1 net vote
1 up votes
0 down votes
Active
(@rpate0)

Goal 1: Promote Human Health

Prevention of Obesity

What are the behavioral factors that predispose to excessive weight gain and development of obesity? And, which intervention strategies can effectively prevent excessive weight gain and obesity? NHLBI, other NIH institutes and the society at-large have invested heavily in research and clinical practice aimed at treatment of obesity (i.e, weight loss in those who are already overweight). However, much less research... more »

Voting

6 net votes
8 up votes
2 down votes
Active
(@teitelbaum)

Goal 4: Develop Workforce and Resources

Predictable and Steady Funding Growth

There is a need for a predictable, steady expansion of funding of NIH. The repetitive booms and busts in research funding are a primary source of the current instability of the biomedical research and training systems. Funding goals should not be simply “more”, or another “doubling”, but instead a trajectory of steady expansion of research funding that can be sustained over the medium-to-long term.

Voting

28 net votes
32 up votes
4 down votes
Active
(@heartjpc)

Goal 1: Promote Human Health

New technologies for Personalized health monitoring: too much or not enough

The development of personalized medicine and the increasing amount of information extracted from individual and patients throughout their life is expected to growth significantly. Multiple types of physiological sensors are currently embedded in everyday-life objects and yet their clinical value and their potential to improve health care is not well defined. It seems fundamental that the NIH develops a core research group/... more »

Voting

5 net votes
13 up votes
8 down votes
Active
(@bavtad)

Goal 2: Reduce Human Disease

Decline in autopsies is an obstacle to understanding bicuspid aortic valve and thoracic aortic disease.

Greater understanding of the incidence, associated mortality, and unique characteristics of bicuspid aortic valve (BAV) and thoracic aortic disease are needed. An increase in autopsies would be an important source in advancing understanding.

Voting

1 net vote
12 up votes
11 down votes
Active
(@flogerfo)

Goal 2: Reduce Human Disease

What are the fundamental molecular mechanisms involved in the vascular response to interventional or surgical injuries?

The pathobiology of restenosis is intimal hyperplasia, a specific form of wound healing. This response to physical injury is essential to prevent hemorrhage and thus has evolved to be highly sensitive, intense, resilient and redundant. It involves a complex interplay between blood elements, endothelial integrity, leukocytes, macrophages, fibroblasts and smooth muscle cells. Modifying this multipronged response has proven... more »

Voting

2 net votes
14 up votes
12 down votes
Active
(@kevinfiscella)

Goal 2: Reduce Human Disease

Inflammation: what is the role of the blood microbiome?

Blood is not continuously sterile. Data from dental studies, blood donors, and random blood cultures document that "normal" human blood often harbors microbes. Sepsis only occurs when immunological regulatory systems fail. Growing evidence link subclinical, potentially transient bacteremia to cardiovascular and other diseases. Could many of the diseases associated with inflammatory markers represent either continuous... more »

Voting

15 net votes
25 up votes
10 down votes
Active