We have done the best we can to mimic the human internal environment in vitro for the discovery, testing, and validation of therapeutics, but there is a critical need to do better. The use of more complex cell-based in vitro models is the result of the recognition of how little predictive power there is in current experimental conditions, even with animal models. With an in vitro environment that goes beyond temperature to encompass accurate human local oxygen levels, nutrients, shear stress, cell-cell interactions, and other factors, not only is the time and money to bring effective chemical therapeutics to patients drastically reduced, but cellular therapeutics benefit as well. If we can get it right in vitro, we get it right in vivo.
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